Fig. 3

Hallmark gene sets detected by methods designed to detect differential sample variance (DV) but not differential sample mean (DM) in the childhood B-lineage acute lymphoblastic leukemia (B-ALL) dataset comparing prednisolone-sensitive and prednisolone-resistant patients and in the colon polyps datasets comparing hyperplastic polys and sessile serrated adenoma/polyps. Four prednisolone resistance gene sets from the study that generated the childhood B-ALL dataset were used only with the childhood B-ALL dataset for a sanity check. The association of these gene sets with prednisolone resistance was indicated under column BP_Category. Cells with dark gray color indicate p-value < 0.05. Three annotation columns on the left side indicate the gene sets found to be significant by at least 3 of the 4 used methods for the childhood B-ALL (column DV_B_ALL) and polyps datasets (column DV_polyps), and the biological process category of each gene set (column BP_Category). DV: Differential sample variance, KS: Kolmogorov–Smirnov, MD: Mean deviation, AD: Anderson–Darling, CVM: Cramer Von-Mises, RKS: Radial Kolmogorov–Smirnov, RMD: Radial mean deviation, RAD: Radial Anderson–Darling, RCVM: Radial Cramer Von-Mises