Table 9 Literature search summary for top 10 selected biomarkers
Cancer type | Biomarker | Omics type | Summary |
|---|---|---|---|
BRCA | mir934 [40] | miRNA | Promotes breast cancer metastasis by regulating PTEN and epithelial-mesenchymal transition. |
BRCA | FOXC1 [34] | mRNA | Highly linked to Basal-like subtype, often overexpressed in Basal-like cancers. Regulates genes involved in cell growth, differentiation, and survival. |
BRCA | mRNA | Work together in Luminal subtypes to regulate gene expression in response to estrogen and drive the growth of estrogen receptor-positive tumors. | |
BRCA | FOXA1 [37] | mRNA | Facilitates ESR1 binding to its target genes, aiding transcriptional regulation in Luminal breast cancer cells. |
BRCA | C6orf97 [38] | mRNA | Not well-characterized; located near ESR1 and may influence breast cancer susceptibility. |
BRCA | AGR3 [39] | mRNA | Associated with estrogen receptor-positive breast cancer. |
BRCA | TBC1D9 [41] | mRNA | An important modulator of tumorigenesis in breast cancer. |
BRCA | RAET1L | mRNA | Limited publication information; highly ranked biomarkers worth investigating for potential breast cancer connections. |
BRCA | MIR563 | DNA Meth. | Limited publication information; highly ranked biomarkers worth investigating for potential breast cancer connections. |
KIPAN | mir126 [42] | miRNA | Downregulated in kidney cancer, including KIRC. Involved in tumor progression and metastasis |
KIPAN | VEGFA [43] | mRNA | Frequently overexpressed in KIRC, targeted by anti-angiogenic therapies. |
KIPAN | mir122 [44] | miRNA | Often downregulated in kidney cancer, influences tumor progression by regulating metabolic pathways. |
KIPAN | MTUS1 [45] PLVAP [46] PRDM16 [47] SLC22A23 [48] | mRNA | Dysregulated in kidney cancer, contributes to tumor development and progression. |
KIPAN | TSPAN5 | mRNA | Limited publication information; highly ranked biomarkers worth investigating for potential breast cancer connections. |
KIPAN | SNORB30 UBE2N | DNA Meth. | Limited publication information; highly ranked biomarkers worth investigating for potential breast cancer connections. |