Table 8 Performance of the models by removing one ATC code kernel
Removed ATC code kernel | Information used for constructing ATC code kernel | Second level | Third level | Fourth level | |||
|---|---|---|---|---|---|---|---|
AUROC | AUPR | AUROC | AUPR | AUROC | AUPR | ||
\(K_{TP,a}^{i, * }\) | Related target proteins of ATC codes | 0.9591 | 0.9640 | 0.9668 | 0.9696 | 0.9694 | 0.9713 |
\(K_{SE,a}^{i, * }\) | Related side effects of ATC codes | 0.9593 | 0.9641 | 0.9668 | 0.9695 | 0.9695 | 0.9714 |
\(K_{FP,a}^{i, * }\) | Related structural features of ATC codes | 0.9588 | 0.9634 | 0.9660 | 0.9687 | 0.9685 | 0.9709 |
\(K_{F,a}^{i, * }\)# | Known drug-ATC code associations | 0.9592 | 0.9643 | 0.9648 | 0.9681 | 0.9719 | 0.9724 |
\(K_{{SP{\text{ro}}}}^{i}\)# | ATC code tree [24] | 0.9598 | 0.9643 | 0.9680 | 0.9706 | 0.9719 | 0.9723 |
\(K_{SM}^{i}\)# | Numbers or letters in ATC codes [26] | 0.9243 | 0.9451 | 0.9535 | 0.9591 | 0.9679 | 0.9676 |