Fig. 1

Procedures for inferring biological profiles of ATC codes. Six different association types are employed to construct target protein-related, fingerprint-related, and side effect-related association networks. The random walk with restart algorithm is adopted to infer related target proteins, structural features, and side effects for each ATC code, followed by a permutation test to control false positives. The final biological profiles of ATC codes include highly related target proteins, structural features, and side effects