Fig. 5
Comparison of chromatin loop detection by DconnLoop, Peakachu, dloopcaller, Mustache, and Chromosight on GM12878 cells. A Venn diagram of loops predicted by different tools. B Number of loops supported by ChIA-PET, HiChIP, and Capture Hi-C experimental techniques among all detected results on chromosomes 15, 16, and 17. C Enrichment level of ChIP-seq peaks at CTCF binding sites. D Enrichment level of regulatory elements. E Aggregate peak analysis profiles for target (ChIA-PET and HiChIP identified) and annotated loops. F CTCF motif orientation of loops. G Local significance analysis of loops. H, I Distance distribution of loops. J Loop radius statistics. K, L Visualization comparison of detection results from different tools in small regions on chromosomes 15 and 16