Fig. 9
From: AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs
O-GlcNAc analysis with AMEND: active module obtained from AMEND. Seed values for AMEND are equivalent change indices (ECIs), which are weighted ratios of log fold changes between OGT knockout vs. Control at 1 week and OGT knockout versus control at 2 weeks from differential expression analyses of transcriptomic, proteomic, phospho-proteomic, and metabolomic data. Samples come from mouse liver. Darker grey nodes represent nodes with ECIs closer to 1 (more equivalently changed between treatment–control comparisons). Red, orange, pink, and blue node borders correspond to the transcriptomic, proteomic, phospho-proteomic, and metabolomic components, respectively