Fig. 2
From: A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures
Plate diagram for the Dirichlet-multinomial model. The random intercepts \(\textbf{u}_i\) are independent of clonality-based grouping, and in log-ratio space, as are the coefficients \(\varvec{\beta }\). The precision parameters \(\varvec{\lambda }\) are a function of the clonality-based grouping exclusively in this manuscript, but adjustable in their implementation. Similarly, \(\textbf{X}\) and \(\textbf{D}\) (the covariate matrices for the fixed effects and precision) are shared here and reflect the clonality group g, but that need not be the case and they are specified independently in the model implementation