Fig. 4

Flowchart for the Typical in silico Inclusivity Evaluation Using the Coronavirus Monitoring for Inclusivity (CoMIT) Pipeline. The CoMIT pipeline requires two inputs: GISAID sequence submissions restricted by complete, high coverage and human-host filters and GISAID sequence metadata. The dotted red line highlights the portion of the pipeline involved in a Variant Sorter Run, including processing by the Variant Sorter Algorithm. Results are captured in a SQLite database where SQL queries are leveraged as inputs for the visualization and summary code (in R). Outputs of the pipeline are the visualizations. A variant mapping file is updated for each evaluation using: two website sources [17, 18]; DBMS: database management system; GISAID: Global Initiative on Sharing Influenza Data; and SQL: structured query language