A graph neural network approach for hierarchical mapping of breast cancer protein communities

BMC Bioinformatics

Table 3 FDA approved drugs that target the system HOST:37, Transcriptional Regulation. A total of 38 unique drugs were identified. Drugs with different possible doses and durations were selected based on significance in alteration of target survival (lowest q-value)

Small molecule	Dose (M)	Duration (h)	p-value	q-value
Alpha-estradiol	1.00E−08	6	0.002	0.0488
Alprostadil	1.00E−05	6	0.002	0.0475
Amitriptyline	1.00E−06	6	0.002	0.0408
Azathioprine	1.00E−04	6	0.002	0.0439
Celecoxib	1.00E−05	6	0.002	0.0418
Chlorpromazine	1.00E−06	6	0.002	0.0408
Chlorpropamide	1.00E−04	6	0.002	0.0488
Ciclosporin	1.00E−06	6	0.002	0.0428
Clofibrate	1.00E−04	6	0.002	0.045
Colchicine	1.00E−07	6	0.002	0.0408
Daunorubicin	1.00E−06	6	0.002	0.0428
Deferoxamine	1.00E−04	6	0.002	0.0488
Dinoprostone	1.00E−05	6	0.002	0.0428
Exemestane	1.00E−08	6	0.002	0.0462
Fludrocortisone	1.00E−06	6	0.002	0.0428
Fulvestrant	1.00E−06	6	0.002	0.0399
Haloperidol	1.00E−05	6	0.002	0.0408
Imatinib	1.00E−05	6	0.002	0.0408
Irinotecan	1.00E−04	6	0.002	0.0439
Lomustine	1.00E−04	6	0.002	0.0418
Mercaptopurine	1.00E−04	6	0.002	0.0408
Metformin	1.00E−05	6	0.002	0.045
Monorden	1.00E−07	6	0.002	0.0418
Nifedipine	1.00E−05	6	0.002	0.0428
Orlistat	1.00E−05	6	0.002	0.0475
Paclitaxel	1.00E−07	6	0.002	0.045
Pioglitazone	1.00E−05	6	0.002	0.0408
Prochlorperazine	1.00E−05	6	0.002	0.0439
Sirolimus	1.00E−07	6	0.002	0.0475
Sodium phenylbutyrate	1.00E−03	6	0.002	0.045
Sulfasalazine	1.00E−04	6	0.002	0.0475
Thalidomide	1.00E−04	6	0.002	0.0439
Thioridazine	1.00E−05	6	0.002	0.0462
Tioguanine	1.00E−05	6	0.002	0.0475
Tretinoin	1.00E−06	6	0.002	0.0399
trifluoperazine	1.00E−05	6	0.002	0.0439
Valproic acid	5.00E−04	6	0.002	0.0418
Vinblastine	1.00E−07	6	0.002	0.0475

ISSN: 1471-2105