Table 4 The corresponding p values of significant SNPs of M-Phen in the analysis of COPDGene using different imputation methods
Chr:bp\(^{1}\) | SNP\(^{2}\) | Unimputed | PHENIX | PIM | C-MSE | C-(0–1) | C-QL |
|---|---|---|---|---|---|---|---|
4:145431497 | rs1512282 | \(1.03E{-9}\) | \(\mathbf {7.33E{-12}}\) | \(9.15E{-12}\) | \(1.11E{-11}\) | \(1.12E{-11}\) | \(1.11E{-11}\) |
4:145434744 | rs1032297 | \(7.69E{-14}\) | \(7.44E{-15}\) | \(7.22E{-15}\) | \(\mathbf {2.55E{-15}}\) | \(2.66E{-15}\) | \(\mathbf {2.55E{-15}}\) |
4:145474473 | rs1489759 | \(1.22E{-16}\) | \(4.44E{-16}\) | \(\mathbf {1.11E{-16}}\) | \(\mathbf {1.11E{-16}}\) | \(\mathbf {1.11E{-16}}\) | \(\mathbf {1.11E{-16}}\) |
4:145485738 | rs1980057 | \(8.14E{-17}\) | \(1.11E{-16}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) |
4:145485915 | rs7655625 | \(9.13E{-17}\) | \(1.11E{-16}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) | \(\mathbf {<1.00E{-16}}\) |
15:78882925 | rs16969968 | \(7.84E{-12}\) | \(3.26E{-14}\) | \(2.20E{-14}\) | \(1.10E{-14}\) | \(\mathbf {1.08E{-14}}\) | \(1.10E{-14}\) |
15:78894339 | rs1051730 | \(8.16E{-12}\) | \(3.10E{-14}\) | \(2.02E{-14}\) | \(9.44E{-15}\) | \(\mathbf {9.33E{-15}}\) | \(9.44E{-15}\) |
15:78898723 | rs12914385 | \(1.48E{-12}\) | \(1.59E{-14}\) | \(4.55E{-15}\) | \(2.11E{-15}\) | \(\mathbf {2.00E{-15}}\) | \(2.11E{-15}\) |
15:78911181 | rs8040868 | \(2.59E{-12}\) | \(6.99E{-15}\) | \(2.89E{-15}\) | \(2.11E{-15}\) | \(\mathbf {2.00E{-15}}\) | \(2.11E{-15}\) |
15:78878541 | rs951266 | \(1.02E{-11}\) | \(6.71E{-14}\) | \(5.87E{-14}\) | \(2.24E{-14}\) | \(\mathbf {2.20E{-14}}\) | \(2.24E{-14}\) |
15:78806023 | rs8034191 | \(7.74E{-11}\) | \(4.17E{-13}\) | \(\mathbf {7.84E{-14}}\) | \(9.41E{-14}\) | \(9.26E{-14}\) | \(9.41E{-14}\) |
15:78851615 | rs2036527 | \(1.77E{-10}\) | \(2.69E{-13}\) | \(6.29E{-14}\) | \(6.04E{-14}\) | \(\mathbf {5.94E{-14}}\) | \(6.04E{-14}\) |
15:78826180 | rs931794 | \(9.09E{-11}\) | \(2.99E{-13}\) | \(\mathbf {7.59E{-14}}\) | \(9.14E{-14}\) | \(9.00E{-14}\) | \(9.14E{-14}\) |
15:78740964 | rs2568494 | \(4.23E{-8}\) | \(8.91E{-11}\) | \(1.01E{-10}\) | \(7.35E{-11}\) | \(\mathbf {7.21E{-11}}\) | \(7.36E{-11}\) |