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Table 3 The corresponding p values of significant SNPs of TATES in the analysis of COPDGene using different imputation methods

From: A novel phenotype imputation method with copula model

Chr:bp\(^{1}\)

SNP\(^{2}\)

Unimputed

PHENIX

PIM

C-MSE

C-(0–1)

C-QL

4:145431497

rs1512282

\(5.77E{-9}\)

\(1.27E{-9}\)

\(1.41E{-9}\)

\(\mathbf {5.13E{-10}}\)

\(5.19E{-10}\)

\(\mathbf {5.13E{-10}}\)

4:145434744

rs1032297

\(6.22E{-13}\)

\(1.20E{-12}\)

\(3.50E{-13}\)

\(\mathbf {8.17E{-14}}\)

\(8.59E{-14}\)

\(\mathbf {8.17E{-14}}\)

4:145474473

rs1489759

\(2.52E{-16}\)

\(4.09E{-15}\)

\(7.08E{-16}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

4:145485738

rs1980057

\(9.35E{-17}\)

\(6.82E{-16}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

4:145485915

rs7655625

\(1.64E{-16}\)

\(1.36E{-15}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

\(\mathbf {<1.00E{-16}}\)

15:78882925

rs16969968

\(2.98E{-8}\)

\(\mathbf {9.90E{-11}}\)

\(6.26E{-10}\)

\(1.88E{-10}\)

\(1.87E{-10}\)

\(1.88E{-10}\)

15:78894339

rs1051730

\(2.63E{-8}\)

\(\mathbf {6.91E{-11}}\)

\(4.30E{-10}\)

\(1.26E{-10}\)

\(1.27E{-10}\)

\(1.26E{-10}\)

15:78898723

rs12914385

\(5.14E{-10}\)

\(\mathbf {1.18E{-12}}\)

\(3.03E{-12}\)

\(1.29E{-12}\)

\(1.24E{-12}\)

\(1.29E{-12}\)

15:78911181

rs8040868

\(2.40E{-9}\)

\(\mathbf {1.89E{-12}}\)

\(1.15E{-11}\)

\(4.70E{-12}\)

\(4.52E{-12}\)

\(4.70E{-12}\)

15:78878541

rs951266

\(5.17E{-8}\)

\(\mathbf {1.91E{-10}}\)

\(1.18E{-9}\)

\(3.54E{-10}\)

\(3.54E{-10}\)

\(3.54E{-10}\)

15:78806023

rs8034191

\(1.02E{-7}\)

\(\mathbf {5.77E{-10}}\)

\(1.87E{-9}\)

\(9.48E{-10}\)

\(9.49E{-10}\)

\(9.48E{-10}\)

15:78851615

rs2036527

\(1.56E{-7}\)

\(\mathbf {4.06E{-10}}\)

\(2.07E{-9}\)

\(7.45E{-10}\)

\(7.44E{-10}\)

\(7.45E{-10}\)

15:78826180

rs931794

\(1.18E{-7}\)

\(\mathbf {4.37E{-10}}\)

\(2.18E{-9}\)

\(9.49E{-10}\)

\(9.49E{-10}\)

\(9.49E{-10}\)

15:78740964

rs2568494

\(2.88E{-5}\)

\(5.85E{-7}\)

\(1.37E{-6}\)

\(4.90E{-7}\)

\(\mathbf {4.77E{-7}}\)

\(4.90E{-7}\)

  1. \(^{1}\)Chr:bp denotes chromosome and base pair position
  2. \(^{2}\)SNP denotes Single Nucleotide Polymorphism
  3. Bold values indicate the smallest p value for the genetic association tests using imputed and unimputed data for each SNP