Table 2 The corresponding p values of significant SNPs of MANOVA in the analysis of COPDGene using different imputation methods

4:145431497

rs1512282

\(1.69E{-9}\)

\(\mathbf {1.47E{-11}}\)

\(1.96E{-11}\)

\(2.40E{-11}\)

\(2.42E{-11}\)

\(2.40E{-11}\)

4:145434744

rs1032297

\(6.52E{-14}\)

\(4.71E{-15}\)

\(6.93E{-15}\)

\(\mathbf {2.02E{-15}}\)

\(2.12E{-15}\)

\(\mathbf {2.02E{-15}}\)

4:145474473

rs1489759

\(1.11E{-16}\)

\(4.96E{-16}\)

\(2.08E{-16}\)

\(\mathbf {7.46E{-17}}\)

\(7.90E{-17}\)

\(7.47E{-17}\)

4:145485738

rs1980057

\(6.68E{-17}\)

\(6.00E{-17}\)

\(2.48E{-17}\)

\(\mathbf {8.00E{-18}}\)

\(8.46E{-18}\)

\(\mathbf {8.00E{-18}}\)

4:145485915

rs7655625

\(7.12E{-17}\)

\(1.39E{-16}\)

\(5.95E{-17}\)

\(\mathbf {2.16E{-17}}\)

\(2.28E{-17}\)

\(\mathbf {2.16E{-17}}\)

15:78882925

rs16969968

\(1.32E{-11}\)

\(4.49E{-14}\)

\(2.71E{-14}\)

\(1.51E{-14}\)

\(\mathbf {1.41E{-14}}\)

\(1.51E{-14}\)

15:78894339

rs1051730

\(1.41 E{-11}\)

\(4.44E{-14}\)

\(2.74E{-14}\)

\(1.40E{-14}\)

\(\mathbf {1.36E{-14}}\)

\(1.40E{-14}\)

15:78898723

rs12914385

\(1.76E{-12}\)

\(1.20E{-14}\)

\(3.44E{-15}\)

\(1.85E{-15}\)

\(\mathbf {1.70E{-15}}\)

\(1.85E{-15}\)

15:78911181

rs8040868

\(2.74E{-12}\)

\(5.78E{-15}\)

\(2.11E{-15}\)

\(1.73E{-15}\)

\(\mathbf {1.61E{-15}}\)

\(1.73E{-15}\)

15:78878541

rs951266

\(1.77E{-11}\)

\(9.20E{-14}\)

\(6.88E{-14}\)

\(3.03E{-14}\)

\(\mathbf {2.95E{-14}}\)

\(3.03E{-14}\)

15:78806023

rs8034191

\(2.14E{-10}\)

\(1.03E{-12}\)

\(\mathbf {1.70E{-13}}\)

\(2.25E{-13}\)

\(2.19E{-13}\)

\(2.25E{-13}\)

15:78851615

rs2036527

\(3.99E{-10}\)

\(4.63E{-13}\)

\(\mathbf {1.04E{-13}}\)

\(1.09E{-13}\)

\(1.06E{-13}\)

\(1.09E{-13}\)

15:78826180

rs931794

\(2.35E{-10}\)

\(7.92E{-13}\)

\(\mathbf {1.75E{-13}}\)

\(2.22E{-13}\)

\(2.17E{-13}\)

\(2.22E{-13}\)

15:78740964

rs2568494

\(1.05E{-7}\)

\(2.63E{-10}\)

\(2.41E{-10}\)

\(1.94E{-10}\)

\(\mathbf {1.89E{-10}}\)

\(1.94E{-10}\)