Fig. 1

Dependence of protein noise on protein mean for different 5’UTR constructs. The yEGFP reporter (bottom) and the ymNeonGreen reporter (top) constructs are treated separately. The use of a log-log scale is adopted from [12]. The dots give the experimental values taken from [12] (see Table 2). Each dot is a result of multiple experiments, and the error bars indicate the standard deviation (SD). These were obtained from the standard deviation of the (nonsquared) coefficient of variation by Taylor formula: \(SD_{CV^2} = 2 CV SD_{CV}\), \(SD_F = \langle P \rangle SD_{CV^2}\). The dashed lines give the linear and hyperbolic dependence of the F and \(CV^2\), respectively, which are predicted by the two-stage gene expression model (cf. (5)). The protein translation rate \(\lambda ^p\) and the mRNA decay rate \(\gamma ^m\) are being varied to change the mean levels. Note that the use of the log-log scale results in a slight curvature of the line (with a nonzero intercept)