Fig. 5

Variability and Reproducibility of LOCC Scores and ROC AUC A The 8-gene modified RISK score was ordered in descending order and plotted against the ranking of the samples. A horizontal line is graphed at 2.00 to separate patients into high and low risk groups using ideal LOCC cutoff. B The LOCC cutoff selection was graphed for the 8-gene RISK score using TCGA hepatocellular data. The most significant cutoff was chosen to separate patients into two groups. In addition, another cutoff at 1.077 was selected for dividing patients into three groups. C A Kaplan–Meier overall survival curve is plotted at the validation cutoff to separate patients into high or low risk score. D A comparison of the RISK score of 8 leading genes by LOCC score and the original 12 gene RISK score is shown. The lowest p value and hazard ratio (HR) are selected with a minimum of at least 10% of the total samples in each group. E Low risk patients are further stratified using the LOCC cutoff selector into middle and low risk. A corresponding Kaplan–Meier graph is plotted for the three different risk group. Patients’ survival times are expressed in months. P values are calculated using log-rank test. HR are calculated using Cox proportional hazard regression