Fig. 2

Validation of E2F1 as prognostic biomarker in the LIRI-JP hepatocellular dataset A The z-score expression of E2F1 from LIRI-JP hepatocellular carcinoma patient samples was ordered in descending order and plotted against the ranking of the samples. A horizontal line is graphed at -0.305 to separate patients into high and low E2F1 groups using the TCGA dataset cutoff. B The LOCC cutoff selection was graphed for LIRI-JP samples. The cutoff from TCGA data was used to separate patients into high and low E2F1 groups. C A Kaplan–Meier overall survival curve is plotted at the validation cutoff to separate patients into high or low E2F1. D A data table of the details of the groups is shown. Patients’ survival times are expressed in days. P values are calculated using log-rank test. HRs are calculated using cox proportional hazard regression. E A ROC is plotted for E2F1 and the AUC was calculated