Fig. 2

Transition of positivity confidence value for increasing the succinate export flux \(c_p(m_{\text{SUCCt}}, \cdot )\). Each square indicates a metabolite in the network. Each arrow indicates a reaction, and its color shows the positivity confidence value (red and blue) or zero response (grey). The reactions corresponding to the edges in this figure are shown in Supplementary Table S5. a Values given by the initial model. b Values given by the model updated by 10 perturbation records that \(y_i = -1\) where \(m_i=m_{\text{SUCCt}}\) and \(j_i=j_{\text{GND}}\). c Values given by the model updated by 10 perturbation records that \(y_i = -1\) where \(m_i=m_{\text{SUCCt}}\) and \(j_i=j_{\text{PTS}}\) in addition to the perturbation records of b