Table 3 Target interactions
From: VAIV bio-discovery service using transformer model and retrieval augmented generation
Relation | Interaction types | Semantic meaning | |
|---|---|---|---|
Chem/Drug-Protein/gene Interaction | CPR:1 | PART-OF | Part-of |
CPR:2 | DIRECT-REGULATOR, INDIRECT-REGULATOR, REGULATOR | Regulator | |
CPR:3 | ACTIVATOR, INDIRECT-UPREGULATOR, UPREGULATOR | Upregulator or activator | |
CPR:4 | DOWNREGULATOR, INHIBITOR, INDIRECT-DOWNREGULATOR, | Downregulator or inhibitor | |
CPR:5 | AGONIST, AGONIST-ACTIVATOR, AGONIST-INHIBITOR | Agonist | |
CPR:6 | ANTAGONIST | Antagonist | |
CPR:7 | MODULATOR, MODULATOR-ACTIVATOR, MODULATOR-INHIBITOR | Modulator | |
CPR:8 | COFACTOR | Cofactor | |
CPR:9 | SUBSTRATE, SUBSTRATE_PRODUCT-OF, PRODUCT-OF | Substrate or product-of | |
CPR:10 | NOT | Non-interacting entities | |
Drug-Drug Interaction | DDI-Mechanism | a pharmacokinetic interaction mechanism | |
DDI-Effect | the effect of an interaction | ||
DDI-Advice | a recommendation or advice regarding the concomitant use of two drugs | ||
DDI-Int | the sentence mentions that interaction occurs and does not provide any detailed information about the interaction | ||
DDI-False | Non-interacting entities | ||
Chem/Drug-Disease Interaction | Potential | the case where certain type of interaction is expected | |
NOT | Non-interacting entities | ||