Be-dataHIVE: a base editing database

BMC Bioinformatics

Table 2 Stratification of the database by base editors for selected metrics

Base editor	Unique guides	Unique targets	Unique PAMS	Avg. sequence length	Avg. length flanking sequence	Avg. efficiency rate full guide*	Avg. efficiency rate 3–10 window*
A3G-CGBE	7205	7205	38	79	59	–	–
A3G-CTD-CGBE	7022	7022	40	79	59	–	–
ABE	29,179	29,179	4	49.70	29.70	0.25	0.20
ABE20m	24,994	24,990	69	79	59	0.17	–
ABE8e	28,962	28,958	69	72.04	52.04	0.22	0.27
ABE-CP1040	16,295	16,295	4	56	36	0.26	–
ABEmax	8558	8558	–	20	–	0.26	0.25
ABERA	14,776	14,776	69	79	59	0.00	–
AID	18,876	18,876	4	56	36	0.41	–
BE3-WT	8522	8522	36	79	59	–	–
BE4	12,607	12,607	4	56	36	0.27	–
BE4-1	14,776	14,776	69	79	59	0.10	–
BE4-2	11,811	11,811	69	79	59	0.09	–
BE4-CP1028	13,534	13,534	4	56	36	0.21	–
CBE	10,221	10,221	4	30	10	0.08	0.07
CBE4max	16,881	16,881	31	46.46	26.46	0.18	0.14
CDA	17,306	17,306	4	56	36	0.31	–
eA3A	12,115	12,446	16	55.37	35.37	0.29	–
eA3A-FNLS-CGBE	7106	7106	33	79	59	–	–
elegan-A3G-CTD-OPTI-CGBE	6885	6885	39	79	59	–	–
elegan-A3G-OPTI-CGBE	7204	7204	36	79	59	–	–
elegan-eA3A-OPTI-CGBE	7369	7369	37	79	59	–	–
elgan-OPTI-CGBE	7921	7921	35	79	59	–	–
evoAPOBEC	16,733	16,733	4	56	36	0.29	–
FNLS	14,776	14,776	69	79	59	0.17	–
H47ES48A	7049	7049	4	56	36	0.33	–
T31A	827	879	16	54.06	34.06	0.22	–
T31AT44A	3089	3135	16	55.66	35.66	0.22	–
T44DS45A	1101	1101	4	56	36	0.19	–
Target-AID	10,177	10,177	–	20	–	0.13	0.05
YE1-FNLS-BE3	8021	8021	34	79	59	–	–
YE1-FNLS-CGBE	7040	7040	33	79	59	–	–

Please note that for some base editors certain metrics cannot be computed based on the underlying data and are therefore shown as –. For example, efficiency rates cannot be calculated based on bystander data alone as one could have multiple edits occurring at different positions within the same read (for a more detailed explanation please see Sect. "Base editing prediction tasks")
*Calculated rate is used if no efficiency rate is reported

ISSN: 1471-2105