Fig. 4

Mouse embryo single-cell gene expression and methylation multiomics data analysis results. A UMAP plot of scMaui latent factor extracted from the entire dataset. The plots are coloured by embryo stages and populations each. B Latent values in different stages of embryo cells. Latent factors 24 and 42 are presented at the left and the middle. The right boxplot shows the latent factor 24 values by embryo stage only in epiblast cells. C Diagram of embryonic cell developmental lineage. D Latent values normalised between 0 and 1 and ordered by population. E Median correlation between each latent factor and methylation level of each region group. The groups were decided based on clustering methylation levels. F Gene expression of Rex2 and Susd2 over all single-cell samples