Table 3 Functional enrichment of GO for part of DNB
Enriched items | Genes | p-value |
|---|---|---|
Cell surface receptor signaling pathway (GO:0007166) | GCD3G, CD3D, CD8A, CD3E, CCR1, CD247, CXCR1, FADD, IL7R, IL17RA, IFNAR2, LILRB2, TNFSF10, MYD88, CCR5, LILRB3, CD2, KLRD1, CD14, CD27, CD28 | 5.57E-21 |
Immune response (GO:0006955) | IL18RAP, AQP9, CD8A, GZMA, CCR1, HLA-DMB, GZMH, IL7R, HLA-DMA, LILRB2, TNFRSF1B, TNFSF10, CCR5, IL4R, IRF8, ZAP70, HLA-DPA1, CD27, PTAFR, HLA-DRA | 1.50E-13 |
T cell costimulation (GO:0031295) | CD3G, TRAC, CD3D, CD3E, LGALS1, CD247, LCK, HLA-DPA1, CD5, HLA-DRA, CD28 | 4.77E-12 |
T cell receptor signaling pathway (GO:0050852) | CD3G, TRAC, CD3D, CD3E, GATA3, CD247, LCK, ZAP70, HLA-DPA1, HLA-DRA, PIK3R2, CD28 | 1.61E-10 |
Apoptotic process (GO:0006915) | PRF1, GZMA, LGALS1, LY86, TGFBR2, FADD, GZMB, ZBTB16, GZMH, TNFSF10, MYD88, RIPK1, MAP3K1, CD2, CTSH, CD14 | 1.03E-07 |