Fig. 1
From: Identifying miRNA sponge modules using biclustering and regulatory scores
The pipeline of miRSM. We construct miRNA-mRNA correlation matrix using Pearson method, and miRNA-mRNA context++ score matrix using putative miRNA-target binding information. Next, miRNA-mRNA regulatory score matrix is inferred by combining miRNA-mRNA correlation and context++ score matrix. A biclustering method is then used to generate miRNA-mRNA biclusters. We identify miRNA sponge interactions in each miRNA-mRNA bicluster, and remove the candidate miRNA sponges which are not involved in any miRNA sponge interactions. The remaining candidate miRNA sponges and miRNAs in each bicluster are considered as a miRNA sponge module