Fig. 3

Percentage distribution of differentially expressed (DE) genes across clusters of FC average. K-Means clustering applying Pearson correlation as distance metric identifies 7 clusters based on the mean fold change of the 490 DE genes. Cluster_2 includes all down-regulated genes (green). Up-regulated genes (red) are enriched in Cluster_3 and broadly distributed in Cluster_1 and Clusters_ 4–7